A series of 2-aminopyrimidine derivatives, substituted at 5-and 6-positions, were synthesized. The reaction was carried out in a single step by treatment of the corresponding β-ketoester or β-aldehydoester with guanidine hydrochloride in the presence of K2CO3, in a microwave-assisted method without the requirement of solvent. A unique 1: 1 co-crystal structure was obtained which shows that a 6-phenyl-2-aminopyrimidinone forms a strong ...
![3-amino-2,4-diazabicyclo[4.3.0]nona-3,10-dien-5-one Structure](https://image.chemsrc.com/caspic/129/33081-06-0.png)
