Identification of a new antinociceptive alkaloid isopropyl N-methylanthranilate from the essential oil of Choisya ternata Kunth

…, PD Fernandes, F de Sousa Menezes

Index: Radulovic, Niko S.; Miltojevic, Ana B.; McDermott, Michael; Waldren, Steve; Parnell, John Adrian; Pinheiro, Mariana Martins Gomes; Fernandes, Patricia Dias; De Sousa Menezes, Fabio Journal of Ethnopharmacology, 2011 , vol. 135, # 3 p. 610 - 619

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Citation Number: 24

Abstract

Materials and methods The oils were investigated by GC and GC–MS. Synthesized compounds were spectrally characterized (UV–Vis, IR, 1D and 2D NMR, MS). The obtained synthetic samples of compounds were assayed for peripheral and central antinociceptive activity in two models (effects on acetic acid induced writhing in mice and the hot plate test for nociception). Results Detailed GC and GC–MS analyses of the essential oil of Choisya ...