Azathioprine [Imuran; 6-[(l-methyl-4-nitro-1H-imidazol-5-yl) thio]-1H-purine] is a widely used immunosuppressive and antiarthritic drug. For the sake of comparison, the riboside, the 2 '- deoxyriboside, and the arabinoside of azathioprine and its 2-amino congener, thiamiprine, were prepared by an enzymatic method. In vitro, the cytotoxicities of these aglycons and their nucleosides were similar (EDSo= 0.8-2 pM), except for the arabinosides, which were ...
![9H-Purin-2-amine, 9-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-6-[(1-methyl-4-nitro-1 H-imidazol-5-yl)thio]- Structure](https://image.chemsrc.com/caspic/060/61552-42-9.png)
