Abstract An efficient and rapid synthesis of phloroglucide analogs under microwave irradiation is described. The solid-phase condensation reaction of the 4-halo-2, 6-bis (hydroxymethyl) phenols 1a, b with other substituted phenols in the presence of ZnCl 2 afforded the target molecules in much higher yields than by classical solution-phase synthesis and allowed us to prepare new phloroglucide analogs possessing sensitive ...
![4-chloro-2,6-bis[(2-hydroxy-5-methyl-phenyl)methyl]phenol Structure](https://image.chemsrc.com/caspic/315/6640-92-2.png)
![4-chloro-2,6-bis[(3,5-dichloro-2-hydroxyphenyl)methyl]phenol Structure](https://image.chemsrc.com/caspic/035/65302-49-0.png)
![Phenol,4-chloro-2,6-bis[(5-chloro-2-hydroxyphenyl)methyl]- Structure](https://image.chemsrc.com/caspic/306/6642-07-5.png)