Isomeric Control of Protein Recognition with Amino Acid??and Dipeptide??Functionalized Gold Nanoparticles

CC You, SS Agasti, VM Rotello

Index: You, Chang-Cheng; Agasti, Sarit S.; Rotello, Vincent M. Chemistry - A European Journal, 2008 , vol. 14, # 1 p. 143 - 150

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Citation Number: 40

Abstract

Abstract Amino acid and dipeptide-functionalized gold nanoparticles (NPs) possessing L/D- leucine and/or L/D-phenylalanine residues have been constructed in order to target the surfaces of α-chymotrypsin (ChT) and cytochrome c (CytC). Isothermal titration calorimetry (ITC) was conducted to evaluate the binding thermodynamics and selectivity of these NP– protein interactions. The chirality of the NP end-groups substantially affects the resultant ...