Tetrahedron

Synthesis of 2-(alkylamino)-5-{alkyl [(2-oxo-2H-chromen-3-yl) carbonyl] amino}-3, 4-furandicarboxylates using a multi-component reaction in water

M Adib, E Sheikhi, A Kavoosi, HR Bijanzadeh

Index: Adib, Mehdi; Sheikhi, Ehsan; Kavoosi, Azadeh; Bijanzadeh, Hamid Reza Tetrahedron, 2010 , vol. 66, # 47 p. 9263 - 9269

Full Text: HTML

Citation Number: 43

Abstract

A simple synthesis of 2-(alkylamino)-5-{alkyl [(2-oxo-2H-chromen-3-yl) carbonyl] amino}-3, 4- furandicarboxylates via a one-pot multi-component reaction is described. The reactive 1: 1 zwitterionic intermediate generated from the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped at room temperature by coumarin-3-carboxylic acids prepared in situ from a 2-hydroxy aromatic aldehyde and Meldrum's acid to afford the title ...