In a recent note, Smith and Hartung'reported the basic dissociation constants of tropine (pK, 2.9 s) and pseudotropine (~ KB 3.67), and expressed the opinion that the weaker base strength of pseudotropine is consistent with its cis-configuration of the K-CH3 and OH groups, a configuration that has been established by the acyl migration experiments of Fodor and Nador. 2
