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In vitro anti-acanthamoeba action by thioureidic derivatives

C Saturnino, M Buonerba, N Paesano, JC Lancelot…

Index: Saturnino, Carmela; Buonerba, Mariafrancesca; Paesano, Nicola; Lancelot, Jean-Charles; De Martino, Giovanni Farmaco, 2003 , vol. 58, # 9 p. 819 - 822

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Abstract

In previous researches [1], some of us had studied the amoebicidal power of superior homologues of propamidine (Brolene®) and hesamidine (Desomedine®), present in two collyria used for a serious, even if rare, form of keratitis, due to the invasion of the cornea by amoeba of the Acanthamoeba genus. These studies were carried out on the amoeba cysts, which are the resistant forms originating the infection persistence. These molecules belonged to the to 4-4′-diamidino- ...