European Journal of Organic Chemistry

Functionalized tetrazoles from cyanogen azide with secondary amines

YH Joo, JM Shreeve

Index: Joo, Young-Hyuk; Shreeve, Jean'ne M. European Journal of Organic Chemistry, 2009 , # 21 p. 3573 - 3578

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Citation Number: 5

Abstract

Abstract Secondary amines react with cyanogen azide at ambient temperature in water/acetonitrile to provide tetrazole derivatives directly. The scope and limitations with regard to steric hindrance of the amine are discussed. Although reaction yields are moderate, 29–81%, the cyanogen azide reactions provide a direct and versatile route to functionalized tetrazoles that may be especially useful considering the diversity of amines ...