Synthesis, structure–activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B

…, A Lavecchia, E Novellino, O Befani, P Turini…

Index: La Regina, Giuseppe; Silvestri, Romano; Gatti, Valerio; Lavecchia, Antonio; Novellino, Ettore; Befani, Olivia; Turini, Paola; Agostinelli, Enzo Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9729 - 9740

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Citation Number: 22

Abstract

New monoamine oxidase inhibitors were synthesized as indole analogues of a previously reported pyrrole series. Several compounds were potent MAO-A (12, 17, 19–22, 31, 36, and 37) or MAO-B (14, 20, 24, 38, 44, and 46) inhibitors, and had Ki values in the nanomolar concentration range. In particular, 22 (Ki= 0.00092 μM, and SI= 68,478) was exceptionally potent and selective as MAO-A inhibitor. In molecular modeling studies, compounds 22, ...