e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Regiocontrolled Synthesis of Ring??Fused Thieno [2, 3??c] pyrazoles through 1, 3??Dipolar Cycloaddition of Nitrile Imines with Sulfur??Based Acetylenes
JZ Chandanshive, BF Bonini, D Gentili…
Index: Chandanshive, Jay Zumbar; Bonini, Bianca Flavia; Gentili, Denis; Fochi, Mariafrancesca; Bernardi, Luca; Franchini, Mauro Comes European Journal of Organic Chemistry, 2010 , # 33 p. 6440 - 6447
Abstract 1, 3-Dipolar cycloadditions of C-carboxymethyl-N-arylnitrile imines with substituted acetylenes bearing thiol or sulfone groups were studied. The sulfur controls the regiochemistry of the reaction, and this protocol was applied to the synthesis of ring-fused thieno [2, 3-c] pyrazoles.
[Griffiths, Rebecca; Wong, W. Wei-Lynn; Fletcher, Stephen P.; Penn, Linda Z.; Langler, Richard F. Australian Journal of Chemistry, 2005 , vol. 58, # 2 p. 128 - 136]
