Bioorganic & medicinal chemistry letters

Inhibition of human cytomegalovirus protease N o with monocyclic β-lactams

R Deziel, E Malenfant

Index: Deziel; Malenfant Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1437 - 1442

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Citation Number: 57

Abstract

Monocyclic β-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) No. Two series of these inhibitors are described, a peptidyl series of compounds and non-peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed.