Tetrahedron letters

An efficient one-pot synthesis of pyrrolines and tetrahydropyridines from their chloro-precursors via in situ aza-Wittig reaction

…, S Muthukrishnan, RS Murthy, J Sankaranarayanan…

Index: Singh, Pradeep N.D.; Klima, Rodney F.; Muthukrishnan, Sivaramakrishnan; Murthy, Rajesh S.; Sankaranarayanan, Jagadis; Stahlecker, Heidi M.; Patel, Bhavika; Gudmundsdottir, Anna D. Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4213 - 4217

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Citation Number: 31

Abstract

A simple and efficient method for synthesizing pyrrolines and tetrahydropyridines via an intramolecular aza-Wittig reaction has been achieved by microwave irradiation of the corresponding chloro-alkane derivatives in the presence of tertiary phosphite and sodium azide. The in situ formation of the alkyl azides makes this a facile and safe method for aza- Wittig reactions.

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2-acetyl-3,4,5,6-tetrahydropyridine Structure

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6-(1,1-dimethoxy)ethyl-2,3,4,5-tetrahydropyridine Structure

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22217-79-4

5-(4-BROMO-PHEN...


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