Asymmetric syntheses and absolute stereochemistry of 5, 6-dihydro-α-pyrones, a new class of potent HIV protease inhibitors

TM Judge, G Phillips, JK Morris…

Index: Journal of the American Chemical Society, , vol. 119, # 15 p. 3627 - 3628

Full Text: HTML

Citation Number: 44

Abstract

... (R)-4-Phenyl-2,5-oxazolidinone played a critical role in establishing the C3α stereocenter via organocuprate chemistry and the C6 stereocenter via a unique “titanium ... Journal of the American Chemical Society (1990), 112 (22), 8215-16CODEN: JACSAT ; ISSN:0002-7863. ...

 Related Synthetic Route
5-(Trifluoromethyl)-2-pyridinesulfonyl chloride Structure

174485-72-4

5-(Trifluoromet...

(R)-3-((R)-1-(3-aminophenyl)propyl)-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one Structure

174485-90-6

(R)-3-((R)-1-(3...

~81%

Tipranavir Structure

174484-41-4

Tipranavir

(E)-1-Chloro-2-pentene-1-one Structure

33698-85-0

(E)-1-Chloro-2-...

~%

Tipranavir Structure

174484-41-4

Tipranavir

(4R)-3-[(3S)-3-[3-(dibenzylamino)phenyl]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Structure

174590-40-0

(4R)-3-[(3S)-3-...

~%

Tipranavir Structure

174484-41-4

Tipranavir

[R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one Structure

188559-25-3

[R-(R*,R*)]-3-[...

~%

Tipranavir Structure

174484-41-4

Tipranavir

(4R)-3-[(2S,3S)-2-Acetyl-3-[3-[bis(phenylmethyl)amino]phenyl]-1-oxopentyl]-4-phenyl-2-oxazolidinone Structure

188559-10-6

(4R)-3-[(2S,3S)...

~%

Tipranavir Structure

174484-41-4

Tipranavir

(2S,5R)-2-[(1S)-1-[3-(dibenzylamino)phenyl]propyl]-5-hydroxy-1-[(4R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-5-(2-phenylethyl)oct-6-yne-1,3-dione Structure

188559-22-0

(2S,5R)-2-[(1S)...

~%

Tipranavir Structure

174484-41-4

Tipranavir

[R-(E)]-3-(1-Oxo-2-pentenyl)-4-phenyl-2-oxazolidinone Structure

188559-05-9

[R-(E)]-3-(1-Ox...

~%

Tipranavir Structure

174484-41-4

Tipranavir

(E)-1-Chloro-2-pentene-1-one Structure

33698-85-0

(E)-1-Chloro-2-...

~%

(4R)-3-[(3S)-3-[3-(dibenzylamino)phenyl]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Structure

174590-40-0

(4R)-3-[(3S)-3-...

(R)-4-Phenyloxazolidin-2-one Structure

90319-52-1

(R)-4-Phenyloxa...

~%

(4R)-3-[(3S)-3-[3-(dibenzylamino)phenyl]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Structure

174590-40-0

(4R)-3-[(3S)-3-...

[R-(E)]-3-(1-Oxo-2-pentenyl)-4-phenyl-2-oxazolidinone Structure

188559-05-9

[R-(E)]-3-(1-Ox...

~%

(4R)-3-[(3S)-3-[3-(dibenzylamino)phenyl]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Structure

174590-40-0

(4R)-3-[(3S)-3-...

(E)-1-Chloro-2-pentene-1-one Structure

33698-85-0

(E)-1-Chloro-2-...

~%

(2S,5R)-2-[(1S)-1-[3-(dibenzylamino)phenyl]propyl]-5-hydroxy-1-[(4R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-5-(2-phenylethyl)oct-6-yne-1,3-dione Structure

188559-22-0

(2S,5R)-2-[(1S)...

(R)-4-Phenyloxazolidin-2-one Structure

90319-52-1

(R)-4-Phenyloxa...

~%

(2S,5R)-2-[(1S)-1-[3-(dibenzylamino)phenyl]propyl]-5-hydroxy-1-[(4R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-5-(2-phenylethyl)oct-6-yne-1,3-dione Structure

188559-22-0

(2S,5R)-2-[(1S)...

[R-(E)]-3-(1-Oxo-2-pentenyl)-4-phenyl-2-oxazolidinone Structure

188559-05-9

[R-(E)]-3-(1-Ox...

~%

(2S,5R)-2-[(1S)-1-[3-(dibenzylamino)phenyl]propyl]-5-hydroxy-1-[(4R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-5-(2-phenylethyl)oct-6-yne-1,3-dione Structure

188559-22-0

(2S,5R)-2-[(1S)...

(4R)-3-[(3S)-3-[3-(dibenzylamino)phenyl]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one Structure

174590-40-0

(4R)-3-[(3S)-3-...

~%

(2S,5R)-2-[(1S)-1-[3-(dibenzylamino)phenyl]propyl]-5-hydroxy-1-[(4R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-5-(2-phenylethyl)oct-6-yne-1,3-dione Structure

188559-22-0

(2S,5R)-2-[(1S)...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved