Facile and efficient synthesis of indazole derivatives by 1, 3-cycloaddition of arynes with diazo compounds and azomethine imides

T Jin, F Yang, Y Yamamoto

Index: Jin, Tienan; Yang, Fan; Yamamoto, Yoshinori Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 6 p. 957 - 972

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Citation Number: 8

Abstract

Abstract N-Unsubstituted indazoles 3 and 1-arylindazoles 4 are readily available in good to high yields through [3+ 2] cycloaddition of 2-(trimethylsilyl) aryl triflates 1 and diazo compounds in the presence of KF or CsF under mild reaction conditions. Furthermore, we found that azomethine imides also underwent cycloaddition reaction with 2-(trimethylsilyl) phenyl triflates (1a) in the presence of KF to afford indazolone derivatives 6 in moderate ...