The Journal of Organic Chemistry

New methods and reagents in organic synthesis. 3. Diethyl phosphorocyanidate: a new reagent for C-acylation

T Shioiri, Y Hamada

Index: Shioiri,T.; Hamada,Y. Journal of Organic Chemistry, 1978 , vol. 43, p. 3631 - 3632

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Citation Number: 48

Abstract

Summary: Diethyl phosphorocyanidate [DEPC, (Et0)Z- P(O)CN], in combination with triethylamine, has been proved a new efficient reagent for the direct C-acylation of active methylene compounds with carboxylic acids. ... Sir: Recent publications from our laboratory have revealed that diethyl phosphorocyanidate [DEPC, (Et0)2P(O)CN], in combination with triethylamine, may be used for (i) N- acylationl(peptide1 bond formati ~ n ) , ~ - ~ (ii) S-acylation (thiol ester ...

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