Reaction of 2??dimethylaminomethylene??1, 3??diones with dinucleophiles. X. synthesis of 5??substituted ethyl or methyl 4??isoxazolecarboxylates and methyl 4??(2, 2?? …

P Schenone, P Fossa, G Menozzi

Index: Schenone, Pietro; Fossa, Paola; Menozzi, Giulia Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 453 - 457

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Citation Number: 13

Abstract

Abstract Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with hydroxylamine hydrochloride in methanol solution afforded in high yields the relative esters of 5-substituted 4-isoxazolecarboxylic acids II. These esters were hydrolyzed generally with concentrated hydrochloric acid-acetic acid mixtures to the corresponding carboxylic acids in satisfactory yields.