KO t Bu-Mediated Synthesis of Dimethylisoindolin-1-ones and Dimethyl-5-phenylisoindolin-1-ones: Selective C–C Coupling of an Unreactive Tertiary sp3 C–H Bond

BS Bhakuni, A Yadav, S Kumar, S Patel…

Index: Wertjes, William C.; Wolfe, Lydia C.; Waller, Peter J.; Kalyani, Dipannita Organic Letters, 2013 , vol. 15, # 23 p. 5986 - 5989

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Citation Number: 26

Abstract

... J. Org. ... of unreactive tertiary alkyl C–H bonds for carbon–carbon coupling reactions is highly desirable for the synthesis of organic molecules bearing a ... seems to be the key step in this transformation and could be the reason for the excellent selectivity toward a tertiary C–H bond. ...