High-affinity fluorescent ligands for the 5-HT 3 receptor

…, SKV Vernekar, AJ Thompson, JD Hothersall…

Index: Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1151 - 1155

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Citation Number: 11

Abstract

5-HT 3 Rs are members of the Cys-loop family of ligand-gated ion channels which also includes nACh, GABA A , and glycine receptors. 4 These transmembrane proteins enable rapid synaptic transmission in the central and peripheral nervous system and are composed of five pseudosymmetrically arranged subunits surrounding a central ion-conducting pore. The neurotransmitter binding sites are located in the extracellular N-terminal domains at the interface of two adjacent ...