Influence of calcium-induced aggregation on the sensitivity of aminobis (methylenephosphonate)-containing potential MRI contrast agents

J Henig, I Mamedov, P Fouskova, É Tóth…

Index: Henig, Joerg; Mamedov, Ilgar; Fouskova, Petra; Toth, Eva; Logothetis, Nikos K.; Angelovski, Goran; Mayer, Hermann A. Inorganic Chemistry, 2011 , vol. 50, # 14 p. 6472 - 6481

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Citation Number: 13

Abstract

Macrocyclic chelates of lanthanide ions bearing aminobis (methylenephosphonate) side arms via variable linkers exhibit unusual properties in the presence and absence of Ca2+. In contrast to previous Ca-responsive probes, the longitudinal relaxivities decrease upon addition of Ca2+. The behavior is based on a calcium-induced aggregation of the lanthanide complexes.