Novel [2-(4-piperidinyl) ethyl](thio) ureas: synthesis and antiacetylcholinesterase activity

…, E Carilla, A Stenger, P Chopin, M Briley

Index: Vidaluc; Calmel; Bigg; Carilla; Stenger; Chopin; Briley Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 689 - 695

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Citation Number: 33

Abstract

A series of l-ar (o) yl-3-[2-(1-benzyl-4-piperidinyl) ethyl](thio) urea derivatives was synthesized and evaluated for antiacetylcholinesterase activity. Most aroyl (thio) urea derivatives showed potent inhibitory activity in the sub-micromolar range. A comparable potency was obtained with the aryl (thio) urea analogues by replacing the phenyl with a 2- pyridyl group. The substituted guanidine variations proved to be almost inactive whereas ...