Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine …

N Sharma, D Mohanakrishnan, UK Sharma…

Index: Sharma, Nandini; Mohanakrishnan, Dinesh; Sharma, Upendra Kumar; Kumar, Rajesh; Richa; Sinha, Arun Kumar; Sahal, Dinkar European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 350 - 368

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Citation Number: 11

Abstract

Abstract The in vitro blood stage antiplasmodial activity of a series of allylated chalcones based on the licochalcone A as lead molecule was investigated against chloroquine (CQ) sensitive Pf3D7 and CQ resistant PfINDO strains of Plasmodium falciparum using SYBR Green I assay. Of the forty two chalcones tested, eight showed IC 50≤ 5 μM. Structure– activity relationship (SAR) studies revealed 9 {1-(4-Chlorophenyl)-3-[3-methoxy-4-(prop-2- ...