Synthesis of Novel Galactopyranosyl??Derived Spiro Barbiturates

VN Ingle, PK Gaidhane, SS Dutta…

Index: Ingle; Gaidhane; Dutta; Naha; Sengupta Journal of Carbohydrate Chemistry, 2006 , vol. 25, # 8-9 p. 661 - 671

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Citation Number: 3

Abstract

Abstract Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2, which on bromination give 5, 5??dibromobarbituric acids 3. Reaction of α??d??galactose with these 5, 5??dibromo barbituric acids afforded 2, 3?螃窿?d??galactopyrano??1, 4??dioxo??7, 9??diaza?? spiro [4, 5] deca??6, 8, 10??triones 4. The structures of the products have been assigned on the basis of 1H NMR, 13C NMR, FAB??MS, optical activity, and elemental analysis. The title ...