Scalability of microwave-assisted organic synthesis. From single-mode to multimode parallel batch reactors

…, D Dallinger, P Walla, E Van der Eycken…

Index: Stadler, Alexander; Yousefi, Behrooz H.; Dallinger, Doris; Walla, Peter; Van Der Eycken, Erik; Kaval, Nadya; Kappe, C. Oliver Organic Process Research and Development, 2003 , vol. 7, # 5 p. 707 - 716

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Citation Number: 173

Abstract

The direct scalability of microwave-assisted organic synthesis (MAOS) in a prototype laboratory-scale multimode microwave batch reactor is investigated. Several different organic reactions have been scaled-up typically from 1 mmol to 100 mmol scale. The transformations include multicomponent chemistries (Biginelli dihydropyrimidine and Kindler thioamide synthesis), transition metal-catalyzed carbon-carbon cross-coupling protocols ( ...