A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were (2E)-N-(3-chlorophenyl)-3-phenylprop-2- enamide (2c) and (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide (2d) with IC50 values of 0.53 μM and 0.45 μM, respectively. These derivatives exhibited reversible and selective ...
[Stadler, Alexander; Yousefi, Behrooz H.; Dallinger, Doris; Walla, Peter; Van Der Eycken, Erik; Kaval, Nadya; Kappe, C. Oliver Organic Process Research and Development, 2003 , vol. 7, # 5 p. 707 - 716]
