Synthesis

Synthesis of Fmoc-β-homoamino acids by ultrasound-promoted Wolff rearrangement

A Müller, C Vogt, N Sewald

Index: Mueller, Annett; Vogt, Carla; Sewald, Norbert Synthesis, 1998 , # 6 p. 837 - 841

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Citation Number: 74

Abstract

Abstract: A highly efficient protocol for Arndt–Eistert chain elongation of the base-labile fluorenylmethoxycarbonyl (Fmoc) protected _-amino acids by Ag+-catalyzed, ultrasound- promoted Wolff rearrangement of the corresponding _-diazo ketones at room temperature is described. The enantiomeric purity of the products was examined by capillary zone electrophoresis with chiral buffer systems. Key words: Fmoc--homoamino acids, Wolff ...