Chemistry–An Asian Journal

Applying small molecule microarrays and resulting affinity probe cocktails for proteome profiling of mammalian cell lysates

H Shi, M Uttamchandani, SQ Yao

Index: Shi, Haibin; Uttamchandani, Mahesh; Yao, Shao Q. Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2803 - 2815

Full Text: HTML

Citation Number: 13

Abstract

Abstract Small molecule microarrays (SMMs) are proving to be increasingly important tools for assessing protein–ligand interactions, as well as in screening for enzyme substrates and inhibitors, in a high-throughput manner. We previously described an SMM-facilitated screening strategy for the rapid identification of probes against γ-secretase, an aspartic protease. In this article, we extend upon this work with an expanded library of ...