Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor, Using Ring- …

H Cho, Y Iwama, K Okano, H Tokuyama

Index: Cho, Hidetsura; Iwama, Yusuke; Okano, Kentaro; Tokuyama, Hidetoshi Synlett, 2013 , vol. 24, # 7 p. 813 - 816

Full Text: HTML

Citation Number: 7

Abstract

Synthesis of three clinical candidates for medicines, a human urate transporter-1 inhibitor, an arginine vasopressin antagonist, and a 17β-hydroxysteroid dehydrogenase type-3 inhibitor, is described. These compounds were synthesized via construction of their 3, 4-

~90%

~63%

Solvent-and catalyst-free direct reductive amination of alde...

[Nguyen, Quynh Pham Bao; Kim, Taek Hyeon Tetrahedron, 2013 , vol. 69, # 24 p. 4938 - 4943]

Enantioselective synthesis and enhanced circularly polarized...

[Zhang, Yu; Yang, Xinye; Yao, Qizheng; Ma, Dawei Organic Letters, 2012 , vol. 14, # 12 p. 3056 - 3059]

Ligand-free CuCl-catalyzed C–N bond formation in aqueous med...

[Xu, Hua-Jian; Zheng, Fa-Yin; Liang, Yu-Feng; Cai, Zhen-Ya; Feng, Yi-Si; Che, Da-Qing Tetrahedron Letters, 2010 , vol. 51, # 4 p. 669 - 671]

Ruthenium??Catalyzed Nitro and Nitrile Compounds Coupling wi...

[Cui, Xinjiang; Zhang, Yan; Shi, Feng; Deng, Youquan Chemistry - A European Journal, 2011 , vol. 17, # 9 p. 2587 - 2591]

Metal-free carbon–nitrogen bond-forming coupling reaction be...

[Ou, Lili; Shao, Jiaan; Zhang, Guolin; Yu, Yongping Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1430 - 1431]