Abstract Reaction of the eneamine 1 formed in situ from isoquinoline and sodium triethylborohydride with aromatic dialdehydes 3 produces 4, 4′-coupled bis (isoquinolines) 4 in good yields. These compounds are readily oxidized with manganese dioxide to the corresponding diketones 5.
[Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806]
