[1, 2, 3] Triazolo [4, 5-h] quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains

…, M Palomba, G Paglietti, P Molicotti, B Paglietti…

Index: Carta, Antonio; Palomba, Michele; Paglietti, Giuseppe; Molicotti, Paola; Paglietti, Bianca; Cannas, Sara; Zanetti, Stefania Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4791 - 4794

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Citation Number: 39

Abstract

In this preliminary study we report the activity of 3-methyl-9-substituted-6-oxo-6, 9-dihydro- 3H-[1, 2, 3]-triazolo [4, 5-h] quinolone-carboxylic acids and their esters as a new class of antiinfective agents against MDR Mycobacterium tuberculosis. In antitubercular screening against H37Rv and 11 clinically isolated strains of M. tuberculosis several derivatives (1o, 3a, c, i, j, p) showed MIC90 in the range 0.5–3.2 μg/mL. 3c showed no cytotoxicity and ...