3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

IM Bell, SN Gallicchio, M Abrams…

Index: Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2388 - 2409

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Citation Number: 86

Abstract

... Journal of Medicinal Chemistry. ... Chemical Methods. Scheme 1 describes the synthetic steps that were generally used for the construction of these macrocyclic FTIs, with compound 11 as an example. Commercially ...