Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. II.

…, A Yokomizo, Y YOKOMIZO, T HOSOKAMI…

Index: Takeda, Yasuyuki; Kawagoe, Keiichi; Yokomizo, Aki; Yokomizo, Yoshihiro; Hosokami, Toru; Shimoto, Yoshimasa; Tabuchi, Yoshiaki; Ogihara, Yoshiyasu; Otsubo, Rira; Honda, Yuko; Yokohama, Shuichi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 951 - 961

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Citation Number: 9

Abstract

A series of phenoxyacetanilide derivatives was synthesized and their antagonist activities for human gastrin/cholecystokinin (CCK)-B and CCK-A receptors were evaluated. Among the compounds synthesized, 2-[3-[3-[N-[2-(N-methyl-N-phenylcarbamoylmethoxy) phenyl]-N-(N- methyl-N-phenylcarbamoylmethyl) carbamoylmethyl]-ureido] phenyl] acetic acid (20i, DA- 3934) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A ...