The Journal of Organic Chemistry

Oligonucleotide synthesis. 10.(8-Quinolinesulfonyl) tetrazole: a new type of highly efficient coupling agent for the synthesis of ribooligonucleotides by the …

H Takaku, M Yoshida

Index: Takaku, Hiroshi; Yoshida, Masatoshi Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 589 - 593

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Citation Number: 23

Abstract

The chemical synthesis of deoxyribonucleotides has developed sufficiently to produce long deoxyribooligonucleotides of defined sequence; whereas because of the presence of the 2'- hydroxyl group, developments for the chemical synthesis of long ribooligonucleotides of defined sequence have been much slower. In our original studies on the synthesis of ribooligonucleotides by the phosphotriester approach, we developed 8-quinolinesulfonyl ...