Catalyst??Free Protocol for the Synthesis of Quinoxalines and Pyrazines in PEG

TQ Huang, WY Qu, JC Ding, MC Liu…

Index: Huang, Tie-Qiang; Qu, Wen-Yan; Ding, Jin-Chang; Liu, Miao-Chang; Wu, Hua-Yue; Chen, Jiu-Xi Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 2 p. 293 - 297

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Citation Number: 3

Abstract

Abstract A facile and simple catalyst-free protocol has been developed for the condensation of 1, 2-diketones with aromatic 1, 2-diamines in polyethylene glycol (PEG), providing quinoxaline derivatives in good yields. The important features of the methodology are broad substrates scope, simple workup, catalyst free, environmentally benign, and no requirement for metal catalysts. It is noteworthy that the cyclization reaction of 1, 2-diketones with ...