Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl) phenyl]-1-propen-3-yl]-2, 3-dihydro-5-benzofuranol, a potent topical …

ML Hammond, RA Zambias, MN Chang…

Index: Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918

Full Text: HTML

Citation Number: 51

Abstract

We have recently reported a series of 2, 3-dihydro-5-benzofuranols that are potent antioxidant-based inhibitors of leukotriene biosynthesis in human PMNs.'O In particular we pointed out that within this series the ability to inhibit leukotriene biosynthesis is directly correlated with the overall lipophilicity of the molecule. We now report our earlier studies in this area in which several closely related ring systems were compared and the 2, 3- ...