Synthetic ceramide analogues as skin permeation enhancers: structure–activity relationships

K Vávrová, A Hrabálek, P Doležal, L Šámalová…

Index: Vavrova, Katerina; Hrabalek, Alexandr; Dolezal, Pavel; Samalova, Lucie; Palat, Karel; Zbytovska, Jarmila; Holas, Tomas; Klimentova, Jana Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 24 p. 5381 - 5390

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Citation Number: 33

Abstract

The study presents new information about the structure–activity relationships of the skin permeation enhancers. A series of ceramide analogues including eight different polar head groups and six different chain lengths was synthesised. The compounds were evaluated as permeation enhancers in vitro using porcine skin. The physico-chemical parameters of the tested compounds obtained by computer modelling were used to evaluate, by multiple ...