Heme Oxygenase Inhibition by 1??Aryl??2??(1H??imidazol??1??yl/1H??1, 2, 4??triazol??1??yl) ethanones and Their Derivatives

…, JZ Vlahakis, D Vukomanovic, K Nakatsu…

Index: Roman, Gheorghe; Vlahakis, Jason Z.; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A. ChemMedChem, 2010 , vol. 5, # 9 p. 1541 - 1555

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Citation Number: 14

Abstract

Abstract Previous studies by our research group have been concerned with the design of selective inhibitors of heme oxygenases (HO-1 and HO-2). The majority of these were based on a four-carbon linkage of an azole, usually an imidazole, and an aromatic moiety. In the present study, we designed and synthesized a series of inhibition candidates containing a shorter linkage between these groups, specifically, a series of 1-aryl-2-(1H-imidazol-1-yl/ ...