Organic letters

High-yielding intramolecular direct arylation reactions with aryl chlorides

LC Campeau, P Thansandote, K Fagnou

Index: Campeau, Louis-Charles; Thansandote, Praew; Fagnou, Keith Organic Letters, 2005 , vol. 7, # 9 p. 1857 - 1860

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Citation Number: 191

Abstract

An N-heterocyclic carbene palladium catalyst system is used to promote direct arylation of a broad range of aryl chlorides to form six-and five-membered ring biaryls. An influence of the halide on the palladium precatalyst on catalyst activation has been revealed, as has a beneficial effect of NHC salts that allows the turnover numbers to be increased by simple addition of imidazolium salts to the reaction mixture.