2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT 2C antagonist with potential anxiolytic properties

JI Andres, JM Alonso, J Fernandez, L Iturrino…

Index: Andres, J Ignacio; Alonso, Jose M; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F; Sipido, Victor K Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3573 - 3577

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Citation Number: 20

Abstract

Following the program started at Johnson & Johnson Pharmaceutical Research & Development searching for 5-HT2A/2C antagonists, we now report on the synthesis of 2- (dimethylaminomethyl)-2, 3, 3a, 8-tetrahydroisoxazolo [3, 2-a] pyrido [3, 4-c]-[2] benzazepine and 2-(dimethylaminomethyl)-2, 3, 3a, 8-tetrahydroisoxazolo [3, 2-a] pyrido [3, 2-c]-[2] benzazepine. A new method for the synthesis of pyridobenzazepines is described as well. ...