4-Amino [1, 2, 4] triazolo [4, 3-a] quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants

R Sarges, HR Howard, RG Browne…

Index: Sarges, Reinhard; Howard, Harry R.; Browne, Ronald G.; Lebel, Lorraine A.; Seymour, Patricia A.; Koe, B. Kenneth Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2240 - 2254

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Citation Number: 356

Abstract

The compounds prepared in this SAR investigation are listed in Tables I-IV and are arranged according to modifications of the substituent X in position 1 which ranges from hydrogen to lower alkyl, trifluoromethyl, pentafluoroethyl, phenyl, methoxy, and hydroxy. Modification of substituent Y in the 4-position is explored within such subgroups and ranges from NH2 to acylated and mono-or dialkylated amines. Substituents 2 in the 6-, 7-, and 8- ...

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