Improved Synthesis of 2??Hydroxy??4, 4, 6??Trimethyl??2, 5??Cyclohexadienone, Useful as a Flavoring Additive

LD Buyck, Y Zi??Peng, R Verhé…

Index: Buyck, Laurent de; Zi-Peng, Yao; Verhe, Roland; Kimpe, De Norbert; Schamp, Niceas Bulletin des Societes Chimiques Belges, 1985 , vol. 94, # 1 p. 75 - 80

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Citation Number: 3

Abstract

Abstract The title dienone 1, useful for modification, improvement or increasing organoleptic properties of tobacco, sucrose syrups, flavored beverages, was prepared in 40–558 overall yield from isophorone, by chlorination of 2-hydroxy-isophorone (2), rearrangement into 6- chloro-2-hydroxyisophorone (5) and de-hydrochlorination. An excellent yield of 3-chloro-2- hydroxy-4, 4, 6-trimethyl-2, 5-cyclohexenone (12) was obtained by chlorination of 5 ...