Organic process research & development

Solvent applications of 2-methyltetrahydrofuran in organometallic and biphasic reactions

DF Aycock

Index: Aycock, David F. Organic Process Research and Development, 2007 , vol. 11, # 1 p. 156 - 159

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Citation Number: 175

Abstract

2-Methyltetrahydrofuran (MeTHF) is a commercially available solvent that is produced from renewable resources. The properties of MeTHF place it between tetrahydrofuran (THF) and diethyl ether in solvent polarity and Lewis base strength. In many cases, MeTHF can replace THF in organometallic reactions. The formation and reaction of Grignard reagents in MeTHF and THF are similar. MeTHF can be used as a solvent for low-temperature lithiation, for ...