Tetrahedron

Total synthesis of PDE-I and-II by copper-mediated double aryl amination

K Okano, N Mitsuhashi, H Tokuyama

Index: Okano, Kentaro; Mitsuhashi, Nakako; Tokuyama, Hidetoshi Tetrahedron, 2013 , vol. 69, # 51 p. 10946 - 10954

Full Text: HTML

Citation Number: 6

Abstract

Abstract A concise total synthesis of PDE-I and-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs 2 CO 3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and unexpected formation of an indole via removal of an Ns group followed by rearomatization. The ...