Iridium??Catalyzed Condensation of Amines and Vicinal Diols to Substituted Piperazines

LLR Lorentz??Petersen, LU Nordstrøm…

Index: Lorentz-Petersen, Linda L. R.; Nordstrom, Lars Ulrik; Madsen, Robert European Journal of Organic Chemistry, 2012 , # 34 p. 6752 - 6759

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Citation Number: 10

Abstract

Abstract A straightforward procedure is described for the synthesis of piperazines from amines and 1, 2-diols. The heterocyclization is catalyzed by [Cp* IrCl 2] 2 and sodium hydrogen carbonate and can be achieved with either toluene or water as solvent. The transformation does not require any stoichiometric additives and only produces water as the byproduct. The reaction can be performed between a 1, 2-diamine and a 1, 2-diol or by a ...

~71%

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~80%

~61%

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