The Journal of Organic Chemistry

N. omega.-Alkoxycarbonylation of. alpha.,. omega.-diamino acids with 2-(trimethylsilyl) ethyl 4-nitrophenyl carbonate

A Rosowsky, JE Wright

Index: Rosowsky, Andre; Wright, Joel E. Journal of Organic Chemistry, 1983 , vol. 48, # 9 p. 1539 - 1541

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Citation Number: 43

Abstract

In connection with a larger project in peptide synthesis, we had a need for Nu-protected derivatives of a, w-diamino acids from which the protecting group could be cleaved under mild neutral conditions. A further requirement was that the protecting group had to be compatible with both benzyloxycarbonyl (Z) and tert-butyloxycarbonyl (Boc) groups. The [2- (trimethylsilyl) ethoxy] carbonyl (Teoc) group,'+ which is easily cleaved at room ...