Well-defined chiral spiro iridium/phosphine-oxazoline cationic complexes for highly enantioselective hydrogenation of imines at ambient pressure

…, JB Xie, YZ Zhang, S Li, QL Zhou

Index: Zhu, Shou-Fei; Xie, Jian-Bo; Zhang, Yong-Zhen; Li, Shen; Zhou, Qi-Lin Journal of the American Chemical Society, 2006 , vol. 128, # 39 p. 12886 - 12891

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Citation Number: 143

Abstract

New chiral phosphine-oxazoline ligands (7, SIPHOX) with a rigid and bulky spirobiindane scaffold were synthesized, starting with optically pure 7-diphenylphosphino-7'- trifluoromethanesulfonyloxyl-1, 1'-spirobiindane, in four steps in 40-64% overall yield. Iridium complexes of 7, the chiral analogues of the Crabtree catalyst, were generated by coordination of ligands 7 and [Ir (COD) Cl] 2 in the presence of sodium tetrakis-3, 5-bis ( ...