Synthesis of coenzyme Q10

ET Oh, H Jin Kim, J Taek Oh, L Su, I Yun…

Index: Oh, Eun-Taek; Taek Oh, Jung; Koo, Sangho; Jin Kim, Hee; Su, Liang; Yun, Inkyun; Nam, Kyunggu; Min, Jae-Hong; Woo Kim, Joon European Journal of Organic Chemistry, 2012 , # 26 p. 4954 - 4962,9 Title/Abstract Full Text Show Details Oh, Eun-Taek; Jin Kim, Hee; Taek Oh, Jung; Su, Liang; Yun, Inkyun; Nam, Kyunggu; Min, Jae-Hong; Woo Kim, Joon; Koo, Sangho European Journal of Organic Chemistry, 2012 , # 26 p. 4954 - 4962

Full Text: HTML

Citation Number: 1

Abstract

Abstract A practical synthesis of coenzyme Q 10 has been developed. The route features an improved Friedel–Crafts allylation of tetramethoxytoluene with a para- chlorobenzenesulfonyl-substituted C 5 allylic chloride at 40 C. Replacement of the methyl ether protecting groups of the para-hydroquinone by methoxymethyl groups at Q 1 stage proceeded efficiently, and allowed the facile final oxidation to coenzyme Q 10 to occur ...