e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Radiosynthesis and bioconjugation of [18F] FPy5yne, a prosthetic group for the 18F labeling of bioactive peptides
JAH Inkster, B Guérin, TJ Ruth…
Index: Inkster, James A. H.; Guerin, Brigitte; Ruth, Thomas J.; Adam, Michael J. Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 14 p. 444 - 452
Abstract A new 18 F-based prosthetic group has been prepared for the labeling of azide- modified peptides for use in PET imaging. 2-[18 F] fluoro-3-(hex-5-ynyloxy) pyridine ([18 F] FPy5yne,[18 F]-1) was prepared via efficient nucleophilic heteroaromatic substitution of either the corresponding 2-nitro (2) or 2-trimethylammonium trifluoromethanesulfonate pyridine (3). Best radiochemical yield of [18 F] FPy5yne from 2 was 91% by radioTLC (15 ...
