[18F] FPyKYNE, a fluoropyridine??based alkyne reagent designed for the fluorine??18 labelling of macromolecules using click chemistry

B Kuhnast, F Hinnen, B Tavitian…

Index: Kuhnast, Bertrand; Hinnen, Francoise; Tavitian, Bertrand; Dolle, Frederic Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 9 p. 336 - 342

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Citation Number: 31

Abstract

Abstract FPyKYNE (2-fluoro-3-pent-4-yn-1-yloxypyridine) is a novel fluoropyridine-based structure, designed for the fluorine-18 labelling of macromolecules using copper-catalysed Huisgen 1, 3-dipolar cycloaddition (click chemistry). FPyKYNE (non-labelled as reference), as well as the 2-bromo, 2-nitro and 2-trimethylammonium analogues (as precursors for labelling with fluorine-18), was synthesized in 44, 95, 60 and 41%, respectively, from ...