Synthesis of N6, N6??Dialkyladenine Nucleosides Using Hexaalkylphosphorus Triamides Produced in Situ

…, S Bae, E Rochttis, P Pradhan, A Kumar

Index: Lakshman, Mahesh K.; Choudhury, Asad; Bae, Suyeal; Rochttis, Eliezer; Pradhan, Padmanava; Kumar, Amit European Journal of Organic Chemistry, 2009 , # 1 p. 152 - 159

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Citation Number: 3

Abstract

Abstract Reactions between secondary amines and phosphorus trichloride (PCl 3) leads to the formation of the corresponding tris (dialkylamino) phosphanes or hexaalkylphosphorus triamides [HAPTs:(R 2 N) 3 P]. Treatment of silyl-protected 2′-deoxyinosine and acetyl- protected inosine with the HAPTs produced in situ, together with iodine (I 2), leads to the formation of N 6, N 6-dialkyladenosine and-2′-deoxyadenosine. In some cases the ...